| Publication number |
CLPUB00596 |
|---|
| Authors |
Tagawa T., Nomura J., Kihira H., Murata M. |
|---|
| Title |
A new established osteosarcoma cell line from human mandible. |
|---|
| Citation |
Mie Med. J. 39:279-286(1989) |
|---|
| Abstract |
The characteristics of a cell line HOSM-2, which derived from osteosarcoma
of human mandible, were investigated. The cultures consisted mainly of
polygonal cells, which had an epithelial-like growth pattern with a
tendency to pile up. The cells produced both alkaline phosphatases and
acid phosphatases. Transmission electron micrographs showed the presence
of intercellular collagen filaments. The population doubling time of these
cells was about 74.8 hours. The number of chromosomes ranged widely from
59 to 81 with the modal number being 70. This cell line has passed through
over 112 population doublings since its primary culture 2 years and 6
months previously. These findings suggest that HOSM-2 are osteosarcoma
cells rather than stromal cells. HOSM-2 may be useful in a variety of
studies of human osteosarcoma.
|
|---|
| Cell lines |
CVCL_A2BJ; HOSM-2 |
|---|
