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Cellosaurus MCF-7/BCRP (CVCL_ZZ40)

[Text version]
Cell line name MCF-7/BCRP
Synonyms MCF-7/Bcrp
Accession CVCL_ZZ40
Resource Identification Initiative To cite this cell line use: MCF-7/BCRP (RRID:CVCL_ZZ40)
Comments Population: Caucasian.
Characteristics: Transfected with a Myc-tagged ABCG2/BCRP.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:74; ABCG2.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=15695404
Imai Y., Ishikawa E., Asada S., Sugimoto Y.
Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2.
Cancer Res. 65:596-604(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ40
Encyclopedic resources Wikidata; Q102114505
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8