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Cellosaurus HaCaT-shNrf2#1 (CVCL_ZW70)

[Text version]
Cell line name HaCaT-shNrf2#1
Accession CVCL_ZW70
Resource Identification Initiative To cite this cell line use: HaCaT-shNrf2#1 (RRID:CVCL_ZW70)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:7782; NFE2L2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=31319135; DOI=10.1016/j.tiv.2019.104602
Choi M., Park M., Lee S., Lee J.W., Choi W.J., Lee C.
Establishment of Nrf2-deficient HaCaT and immortalized primary human foreskin keratinocytes and characterization of their responses to ROS-induced cytotoxicity.
Toxicol. In Vitro 61:104602.1-104602.12(2019)

Cross-references
Encyclopedic resources Wikidata; Q102114089
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8