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Cellosaurus HT1080-MFAP4 W235F-MH (CVCL_ZJ81)

[Text version]
Cell line name HT1080-MFAP4 W235F-MH
Accession CVCL_ZJ81
Resource Identification Initiative To cite this cell line use: HT1080-MFAP4 W235F-MH (RRID:CVCL_ZJ81)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7035; MFAP4 (Note=With p.Trp235Phe and a C-terminal mycHis6 tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=32442478; DOI=10.1016/j.bbagen.2020.129637
Osada Y., Suzuki T., Mizuta H., Mori K., Miura K., Dohmae N., Simizu S.
The fibrinogen C-terminal domain is seldom C-mannosylated but its C-mannosylation is important for the secretion of microfibril-associated glycoprotein 4.
Biochim. Biophys. Acta 1864:129637.1-129637.8(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZJ81
Encyclopedic resources Wikidata; Q98126738
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number11