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Cellosaurus MCF-7/MN1 (CVCL_Z705)

[Text version]
Cell line name MCF-7/MN1
Synonyms MN1; MN-1
Accession CVCL_Z705
Resource Identification Initiative To cite this cell line use: MCF-7/MN1 (RRID:CVCL_Z705)
Comments Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8700512
Bacus S.S., Yarden Y., Oren M., Chin D.M., Lyass L., Zelnick C.R., Kazarov A., Toyofuku W.M., Gray-Bablin J., Beerli R.R., Hynes N.E., Nikiforov M., Haffner R., Gudkov A.V., Keyomarsi K.
Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells.
Oncogene 12:2535-2547(1996)

PubMed=11802204; DOI=10.1002/ijc.1628
Galmarini C.M., Clarke M.L., Falette N., Puisieux A., Mackey J.R., Dumontet C.
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.
Int. J. Cancer 97:439-445(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Z705
Encyclopedic resources Wikidata; Q54904376
Experimental variables resources EFO; EFO_0022548
Entry history
Entry creation10-Apr-2015
Last entry update10-Sep-2024
Version number15