ID   MCF-7/MN1
AC   CVCL_Z705
SY   MN1; MN-1
DR   EFO; EFO_0022548
DR   cancercelllines; CVCL_Z705
DR   Wikidata; Q54904376
RX   PubMed=8700512;
RX   PubMed=11802204;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 10-09-24; Version: 15
//
RX   PubMed=8700512;
RA   Bacus S.S., Yarden Y., Oren M., Chin D.M., Lyass L., Zelnick C.R.,
RA   Kazarov A., Toyofuku W.M., Gray-Bablin J., Beerli R.R., Hynes N.E.,
RA   Nikiforov M., Haffner R., Gudkov A.V., Keyomarsi K.;
RT   "Neu differentiation factor (Heregulin) activates a p53-dependent
RT   pathway in cancer cells.";
RL   Oncogene 12:2535-2547(1996).
//
RX   PubMed=11802204; DOI=10.1002/ijc.1628;
RA   Galmarini C.M., Clarke M.L., Falette N., Puisieux A., Mackey J.R.,
RA   Dumontet C.;
RT   "Expression of a non-functional p53 affects the sensitivity of cancer
RT   cells to gemcitabine.";
RL   Int. J. Cancer 97:439-445(2002).
//