Cellosaurus cell line (CVCL

Cellosaurus (CVCL_Z362)

Comments

Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Population: African American.
Doubling time: 40.6 hours (PubMed=32576280); ~30-40 hours (DSMZ=ACC-738); 62 hours (NCI-DTP=MDA-MB-468); ~47 hours (PBCF); 79.76 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=15677628; Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Fluorescence phenotype profiling.
Omics: Genome sequenced.
Omics: Glycoproteome analysis by proteomics.
Omics: H2BK120ub ChIP-seq epigenome analysis.
Omics: H3K23ac ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K36me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: H3K79me2 ChIP-seq epigenome analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Omics: H3K9me3 ChIP-seq epigenome analysis.
Omics: H4K8ac ChIP-seq epigenome analysis.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=19593635).
Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (PubMed=19593635).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=1961733; PubMed=16541312; PubMed=28889351; ATCC=HTB-132).

HLA typing

Source: PubMed=25960936

Class I
HLA-A	A*23:01,30:02
HLA-B	B*27:03,53:01
HLA-C	C*02:02,04:01

Source: PubMed=26589293

Class I
HLA-A	A*23:01,30:02
HLA-B	B*27:03,53:01
HLA-C	C*02:02,04:01
Class II
HLA-DQ	DQA1*02:01,05:02
	DQB1*03:04,06:13
HLA-DR	DRB1*04:03,13:100

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	80.3
Native American	0
East Asian, North	6.19
East Asian, South	0
South Asian	0
European, North	0
European, South	13.51

Disease

Breast adenocarcinoma (NCIt: C5214)

Species of origin

Aedes pseudoscutellaris (Mosquito) (Stegomyia pseudoscutellaris) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_VH37 (CLA-1)

Sex of cell

Female

Age at sampling

51Y