| Comments |
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: ~60-70 hours (DSMZ=ACC-194).
Microsatellite instability: Stable (MSS) (PubMed=24755471; PubMed=25926053; PubMed=28683746; Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (PubMed=24755471; Cosmic-CLP=910689; DepMap=ACH-000350).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=24755471; PubMed=28683746; Cosmic-CLP=910689; DepMap=ACH-000350).
- Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=16418264).
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| HLA typing |
Source: PubMed=26589293
| Class I | | HLA-A | A*02:01,02:01 | | HLA-B | B*07:02,07:02 | | HLA-C | C*07:02,07:02 |
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| Genome ancestry |
Source: PubMed=30894373
| Origin | % genome |
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|
| African | 2.56 | | Native American | 0.29 | | East Asian, North | 3.34 | | East Asian, South | 0 | | South Asian | 0 | | European, North | 57.97 | | European, South | 35.83 |
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Aedes pseudoscutellaris (Mosquito) (Stegomyia pseudoscutellaris)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Children:
|
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| Sex of cell |
Male |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): Cosmic-CLP=910689; DSMZ=ACC-194; PubMed=25877200; PubMed=25926053
Markers:| Amelogenin | X |
| CSF1PO | 12 |
| D13S317 | 10,13 |
| D16S539 | 9 |
| D18S51 | 11,14 |
| D19S433 | 14 |
| D21S11 | 27,29 |
| D2S1338 | 24 |
| D3S1358 | 15,18 |
| D5S818 | 13,14 |
| D7S820 | 8,12 |
| D8S1179 | 12,13 |
| FGA | 25,27 |
| Penta D | 11,14 |
| Penta E | 10,16 |
| TH01 | 9,9.3 |
| TPOX | 8 |
| vWA | 16,19 |
Run an STR similarity search on this cell line |
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| Web pages |
https://tcpaportal.org/mclp/ |
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| Publications |
Oncogene 6:2033-2040(1991)
Gazdar A.F., Minna J.D.
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Oncogene 7:339-346(1992)
Osborne B.
Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway.
Cell Death Differ. 6:36-47(1999)
Hong Z.-S., Li Z.-H., Kim S.-M., Pian X.-M., Lee D.-H., Yoon J.-T., You S., Choi Y.-J., Kim H.
Establishment and characterization of three immortal bovine muscular epithelial cell lines.
Mol. Cells 21:29-33(2006)
Nat. Commun. 7:11987.1-11987.9(2016)
Morganti R.M., Nishimura T., Ameen M., Wu H.-D., Wernig M., Wu J.C., Majeti R.
Human AML-iPSCs reacquire leukemic properties after differentiation and model clonal variation of disease.
Cell Stem Cell 20:329-344.e7(2017)
Daheron L., Zhu J., Gerszten R.E., Deo R.C., Vasan R.S., O'Donnell C.J., Cowan C.A.
Induced pluripotent stem cell differentiation enables functional validation of GWAS variants in metabolic disease.
Cell Stem Cell 20:547-557.e7(2017)
Cancer Sci. 109:3171-3182(2018)
Correction to: Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Cancer Chemother. Pharmacol. 88:1055-1056(2021)
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 44 |
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