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Cellosaurus B2M-/Etrimer Elf1 (CVCL_YY10)

[Text version]
Cell line name B2M-/Etrimer Elf1
Accession CVCL_YY10
Resource Identification Initiative To cite this cell line use: B2M-/Etrimer Elf1 (RRID:CVCL_YY10)
Comments Characteristics: Using a rAAV, the second B2M allele has been edited to express the signal sequence of HLA-G followed by a flexible (G4S)3 linker followed by B2M covalently linked at the C-terminus to a flexible (G4S)4 linker followed by HLA-E.
Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; 914; B2M (Note=1 of 2 alleles).
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C115 (Elf1)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=28504668; DOI=10.1038/nbt.3860; PMCID=PMC5548598
Gornalusse G.G., Hirata R.K., Funk S.E., Riolobos L., Lopes V.S., Manske G., Prunkard D., Colunga A.G., Hanafi L.-A., Clegg D.O., Turtle C., Russell D.W.
HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells.
Nat. Biotechnol. 35:765-772(2017)

Cross-references
Cell line collections (Providers) WiCell; b2m-etrimer-elf1
Encyclopedic resources Wikidata; Q98125536
Entry history
Entry creation02-Jul-2020
Last entry update30-Jan-2024
Version number5