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Cellosaurus PM1-CCR5-Luc (CVCL_YX98)

[Text version]
Cell line name PM1-CCR5-Luc
Accession CVCL_YX98
Resource Identification Initiative To cite this cell line use: PM1-CCR5-Luc (RRID:CVCL_YX98)
Comments Population: Caucasian.
Characteristics: The luciferase reporter gene expression is under the control of a Tat-inducible SIV LTR.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 1606; CCR5.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
Disease Sezary syndrome (NCIt: C3366)
Sezary syndrome (ORDO: Orphanet_3162)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_YX97 (PM1-Luc)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=32135162; DOI=10.1016/j.jim.2020.112766; PMCID=PMC7188583
Thomas A.S., Ghulam-Smith M., Olson A., Coote C., Gonzales O., Sagar M.
A new cell line for assessing HIV-1 antibody dependent cellular cytotoxicity against a broad range of variants.
J. Immunol. Methods 480:112766.1-112766.9(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YX98
Encyclopedic resources Wikidata; Q98128640
Entry history
Entry creation12-Mar-2020
Last entry update10-Sep-2024
Version number11