ID   PM1-CCR5-Luc
AC   CVCL_YX98
DR   cancercelllines; CVCL_YX98
DR   Wikidata; Q98128640
RX   PubMed=32135162;
CC   Population: Caucasian.
CC   Characteristics: The luciferase reporter gene expression is under the control of a Tat-inducible SIV LTR.
CC   Sequence variation: Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 1606; CCR5.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3366; Sezary syndrome
DI   ORDO; Orphanet_3162; Sezary syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_YX97 ! PM1-Luc
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 10-09-24; Version: 11
//
RX   PubMed=32135162; DOI=10.1016/j.jim.2020.112766; PMCID=PMC7188583;
RA   Thomas A.S., Ghulam-Smith M., Olson A., Coote C., Gonzales O.,
RA   Sagar M.;
RT   "A new cell line for assessing HIV-1 antibody dependent cellular
RT   cytotoxicity against a broad range of variants.";
RL   J. Immunol. Methods 480:112766.1-112766.9(2020).
//