Cellosaurus cell line NCC-MPNST3-X2-C1 (CVCL

Cellosaurus NCC-MPNST3-X2-C1 (CVCL_YU15)

[Text version]

Cell line name

NCC-MPNST3-X2-C1

Synonyms

NCCMPNST3X2C1

Accession

CVCL_YU15

Resource Identification Initiative

To cite this cell line use: NCC-MPNST3-X2-C1 (RRID:CVCL_YU15)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Characteristics: Established from a second generation xenograft established by subcutaneous grafting of tumor tissue into the bilateral hind flanks of female NOD/Shi-scid IL-2Rgammanull mice.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
Doubling time: 64 hours (PubMed=32099531).

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
Mutation; HGNC; HGNC:7765; NF1; Simple; p.Arg816Ter (c.2446C>T); ClinVar=VCV000280055; Zygosity=Heterozygous (PubMed=32099531).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=32099531).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Trp (c.405C>G); ClinVar=VCV000376561; Zygosity=Heterozygous (PubMed=32099531).

Disease

Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_YU14 ! NCC-MPNST3-C1

Sex of cell

Male

Age at sampling

72Y

Category

Cancer cell line

STR profile

Source(s): PubMed=32099531

Markers:

Amelogenin	X,Y
CSF1PO	12
D5S818	12,13
D7S820	12,13
D13S317	8
D16S539	11
D21S11	30
TH01	9
TPOX	8,11
vWA	16

Web pages

https://en.cellline.jp/product/ncc-mpnst3-x2-c1/

Publications

PubMed=32099531; DOI=10.1186/s12935-020-1128-z; PMCID=PMC7031935
Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y., Sakumoto M., Qiao Z.-W., Toki S., Sugawara M., Tanzawa Y., Kobayashi E., Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_YU15
DepMap; ACH-002802

Encyclopedic resources

Wikidata; Q95992537

Entry history

Entry creation

12-Mar-2020

Last entry update

19-Dec-2024

Version number