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Cellosaurus NCC-MPNST3-X2-C1 (CVCL_YU15)

[Text version]
Cell line name NCC-MPNST3-X2-C1
Synonyms NCCMPNST3X2C1
Accession CVCL_YU15
Resource Identification Initiative To cite this cell line use: NCC-MPNST3-X2-C1 (RRID:CVCL_YU15)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Characteristics: Established from a second generation xenograft established by subcutaneous grafting of tumor tissue into the bilateral hind flanks of female NOD/Shi-scid IL-2Rgammanull mice.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo T.).
Doubling time: 64 hours (PubMed=32099531).
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
  • Mutation; HGNC; 7765; NF1; Simple; p.Arg816Ter (c.2446C>T); ClinVar=VCV000280055; Zygosity=Heterozygous (PubMed=32099531).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=32099531).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Trp (c.405C>G); ClinVar=VCV000376561; Zygosity=Heterozygous (PubMed=32099531).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_YU14 ! NCC-MPNST3-C1
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): PubMed=32099531

Markers:
AmelogeninX,Y
CSF1PO12
D5S81812,13
D7S82012,13
D13S3178
D16S53911
D21S1130
TH019
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pages https://en.cellline.jp/product/ncc-mpnst3-x2-c1/
Publications

PubMed=32099531; DOI=10.1186/s12935-020-1128-z
Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y., Sakumoto M., Qiao Z.-W., Toki S., Sugawara M., Tanzawa Y., Kobayashi E., Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YU15
DepMap; ACH-002802
Encyclopedic resources Wikidata; Q95992537
Entry history
Entry creation12-Mar-2020
Last entry update30-Jan-2024
Version number9