ID   NCC-MPNST3-X2-C1
AC   CVCL_YU15
SY   NCCMPNST3X2C1
DR   cancercelllines; CVCL_YU15
DR   DepMap; ACH-002802
DR   Wikidata; Q95992537
RX   PubMed=32099531;
WW   https://en.cellline.jp/product/ncc-mpnst3-x2-c1/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: NCC sarcoma cell line panel.
CC   Population: Japanese.
CC   Characteristics: Established from a second generation xenograft established by subcutaneous grafting of tumor tissue into the bilateral hind flanks of female NOD/Shi-scid IL-2Rgammanull mice.
CC   Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo T.).
CC   Doubling time: 64 hours (PubMed=32099531).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Arg816Ter (c.2446C>T); ClinVar=VCV000280055; Zygosity=Heterozygous (PubMed=32099531).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=32099531).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys135Trp (c.405C>G); ClinVar=VCV000376561; Zygosity=Heterozygous (PubMed=32099531).
ST   Source(s): PubMed=32099531
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8
ST   D16S539: 11
ST   D21S11: 30
ST   D5S818: 12,13
ST   D7S820: 12,13
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   NCIt; C3273; Neurofibromatosis type 1
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_636; Neurofibromatosis type 1
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_YU14 ! NCC-MPNST3-C1
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 30-01-24; Version: 9
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RX   PubMed=32099531; DOI=10.1186/s12935-020-1128-z;
RA   Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y.,
RA   Sakumoto M., Qiao Z.-W., Toki S., Sugawara M., Tanzawa Y., Kobayashi E.,
RA   Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.;
RT   "Establishment and characterization of patient-derived cancer models
RT   of malignant peripheral nerve sheath tumors.";
RL   Cancer Cell Int. 20:58.1-58.15(2020).
//