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Cellosaurus HL-60R (CVCL_YT56)

[Text version]
Cell line name HL-60R
Accession CVCL_YT56
Resource Identification Initiative To cite this cell line use: HL-60R (RRID:CVCL_YT56)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9864; RARA; Simple; p.Gln411Ter (c.1231C>T); Zygosity=Heterozygous; Note=Responsible for retinoic acid resistance (PubMed=1327285).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=1970118; DOI=10.1128/mcb.10.5.2154-2163.1990; PMCID=PMC360563
Collins S.J., Robertson K.A., Mueller L.
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).
Mol. Cell. Biol. 10:2154-2163(1990)

PubMed=1327285; DOI=10.1182/blood.V80.8.1885.1885
Robertson K.A., Emami B., Collins S.J.
Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity.
Blood 80:1885-1889(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YT56
Encyclopedic resources Wikidata; Q94211690
Entry history
Entry creation12-Mar-2020
Last entry update05-Oct-2023
Version number9