ID   HL-60R
AC   CVCL_YT56
DR   cancercelllines; CVCL_YT56
DR   Wikidata; Q94211690
RX   PubMed=1327285;
RX   PubMed=1970118;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln411Ter (c.1231C>T); Zygosity=Heterozygous; Note=Responsible for retinoic acid resistance (PubMed=1327285).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 05-10-23; Version: 9
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RX   PubMed=1327285; DOI=10.1182/blood.V80.8.1885.1885;
RA   Robertson K.A., Emami B., Collins S.J.;
RT   "Retinoic acid-resistant HL-60R cells harbor a point mutation in the
RT   retinoic acid receptor ligand-binding domain that confers dominant
RT   negative activity.";
RL   Blood 80:1885-1889(1992).
//
RX   PubMed=1970118; DOI=10.1128/mcb.10.5.2154-2163.1990;
RA   Collins S.J., Robertson K.A., Mueller L.;
RT   "Retinoic acid-induced granulocytic differentiation of HL-60 myeloid
RT   leukemia cells is mediated directly through the retinoic acid receptor
RT   (RAR-alpha).";
RL   Mol. Cell. Biol. 10:2154-2163(1990).
//