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Cellosaurus HKC-8 (CVCL_Y910)

[Text version]
Cell line name HKC-8
Synonyms HKC8; HKC clone 8
Accession CVCL_Y910
Resource Identification Initiative To cite this cell line use: HKC-8 (RRID:CVCL_Y910)
Comments Doubling time: 20 hours (PubMed=9042817).
Transformant: Ad12-SV40 hybrid virus.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_Y909 ! HKC-5
CVCL_Y911 ! HKC-11
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=9042817; DOI=10.1016/S0022-2143(97)90180-3
Racusen L.C., Monteil C., Sgrignoli A., Lucskay M., Marouillat S., Rhim J.G.S., Morin J.-P.
Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines.
J. Lab. Clin. Med. 129:318-329(1997)

PubMed=11007312; DOI=10.1007/s004240000356
Hara C., Satoh H., Usui T., Kunimi M., Noiri E., Tsukamoto K., Taniguchi S., Uwatoko S., Goto A., Racusen L.C., Inatomi J., Endou H., Fujita T., Seki G.
Intracellular pH regulatory mechanism in a human renal proximal cell line (HKC-8): evidence for Na+/H+ exchanger, CI-/HCO3- exchanger and Na+-HCO3-cotransporter.
Pflugers Arch. 440:713-720(2000)

PubMed=19937734; DOI=10.1002/jcb.22390
Turvey M.R., Wang Y.-Y., Gu Y.-C.
The effects of extracellular nucleotides on [Ca2+]i signalling in a human-derived renal proximal tubular cell line (HKC-8).
J. Cell. Biochem. 109:132-139(2010)

PubMed=31267758; DOI=10.2217/fon-2019-0067
Nogueira I., Dias F., Morais M., Teixeira A.L., Medeiros R.
Everolimus resistance in clear cell renal cell carcinoma: miRNA-101 and HIF-2alpha as molecular triggers?
Future Oncol. 15:2361-2370(2019)

PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662
Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cross-references
Encyclopedic resources Wikidata; Q54889747
Gene expression databases GEO; GSM4009067
GEO; GSM4009068
GEO; GSM4009077
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number9