ID   HKC-8
AC   CVCL_Y910
SY   HKC8; HKC clone 8
DR   GEO; GSM4009067
DR   GEO; GSM4009068
DR   GEO; GSM4009077
DR   Wikidata; Q54889747
RX   PubMed=9042817;
RX   PubMed=11007312;
RX   PubMed=19937734;
RX   PubMed=31267758;
RX   PubMed=33122286;
CC   Doubling time: 20 hours (PubMed=9042817).
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
CC   Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_Y909 ! HKC-5
OI   CVCL_Y911 ! HKC-11
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 10-04-15; Last updated: 29-06-23; Version: 9
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RX   PubMed=9042817; DOI=10.1016/S0022-2143(97)90180-3;
RA   Racusen L.C., Monteil C., Sgrignoli A., Lucskay M., Marouillat S.,
RA   Rhim J.G.S., Morin J.-P.;
RT   "Cell lines with extended in vitro growth potential from human renal
RT   proximal tubule: characterization, response to inducers, and
RT   comparison with established cell lines.";
RL   J. Lab. Clin. Med. 129:318-329(1997).
//
RX   PubMed=11007312; DOI=10.1007/s004240000356;
RA   Hara C., Satoh H., Usui T., Kunimi M., Noiri E., Tsukamoto K.,
RA   Taniguchi S., Uwatoko S., Goto A., Racusen L.C., Inatomi J., Endou H.,
RA   Fujita T., Seki G.;
RT   "Intracellular pH regulatory mechanism in a human renal proximal cell
RT   line (HKC-8): evidence for Na+/H+ exchanger, CI-/HCO3- exchanger and
RT   Na+-HCO3-cotransporter.";
RL   Pflugers Arch. 440:713-720(2000).
//
RX   PubMed=19937734; DOI=10.1002/jcb.22390;
RA   Turvey M.R., Wang Y.-Y., Gu Y.-C.;
RT   "The effects of extracellular nucleotides on [Ca2+]i signalling in a
RT   human-derived renal proximal tubular cell line (HKC-8).";
RL   J. Cell. Biochem. 109:132-139(2010).
//
RX   PubMed=31267758; DOI=10.2217/fon-2019-0067;
RA   Nogueira I., Dias F., Morais M., Teixeira A.L., Medeiros R.;
RT   "Everolimus resistance in clear cell renal cell carcinoma: miRNA-101
RT   and HIF-2alpha as molecular triggers?";
RL   Future Oncol. 15:2361-2370(2019).
//
RX   PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662;
RA   Khundmiri S.J., Chen L.-H., Lederer E.D., Yang C.-R., Knepper M.A.;
RT   "Transcriptomes of major proximal tubule cell culture models.";
RL   J. Am. Soc. Nephrol. 32:86-97(2021).
//