Cellosaurus cell line PGA-1 (CVCL

Cellosaurus PGA-1 (CVCL_Y545)

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Cell line name

PGA-1

Synonyms

PGA1; PG A1; CLL-PGA

Accession

CVCL_Y545

Resource Identification Initiative

To cite this cell line use: PGA-1 (RRID:CVCL_Y545)

Comments

Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: ~50 hours (DSMZ=ACC-766).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.

HLA typing

Source: DSMZCellDive=ACC-766

Class I
HLA-A	A*02:01:01,03:01:01
HLA-B	B*35:03:01,39:01:01
HLA-C	C*07:02:01,12:03:01
Class II
HLA-DP	DPA1*01:03:01,01:03:01
	DPB1*04:02:01,02:01:02
HLA-DQ	DQA1*01:02:01,05:05:01
	DQB1*03:01:01,06:09:01
HLA-DR	DRA*01:02:02,01:02:02
	DRB1*12:01:01,13:02:01

Disease

Chronic lymphocytic leukemia (NCIt: C3163)
B-cell chronic lymphocytic leukemia (ORDO: Orphanet_67038)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_Y555 ! PG/B95-8

Sex of cell

Male

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): DepMap=ACH-001634; DSMZ=ACC-766

Markers:

Amelogenin	X,Y
CSF1PO	13
D2S1338	17,18
D3S1358	15,16
D5S818	11,12
D7S820	10,11
D8S1179	13
D13S317	8,12
D16S539	12
D18S51	15
D19S433	14,15
D21S11	28,30
FGA	20,22
Penta D	9,14
Penta E	12
TH01	6,9.3
TPOX	8,11
vWA	17

Publications

PubMed=2836321; DOI=10.1002/ijc.2910410621
Nongnit Lewin, Pierre Aman, Hakan Mellstedt, Lore Zech, George Klein;
Direct outgrowth of in vivo Epstein-Barr virus (EBV)-infected chronic lymphocytic leukemia (CLL) cells into permanent lines.
Int. J. Cancer 41:892-895(1988)

PubMed=23297799; DOI=10.3109/10428194.2013.764418
Anna Lanemo Myhrinder, Eva Hellqvist, Ann-Charlotte Bergh, Mattias Jansson, Kenneth Nilsson, Per Hultman, Jon Jonasson, Anne Mette Buhl, Lone Bredo Pedersen, Jesper Jurlander, Eva Klein ...Show all 15 authors... , Nicole Weit, Marco Herling, Richard Rosenquist, Anders Rosen; Show fewer authors
Molecular characterization of neoplastic and normal 'sister' lymphoblastoid B-cell lines from chronic lymphocytic leukemia.
Leuk. Lymphoma 54:1769-1779(2013)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-766
NCBI_Iran; C583

Cell line databases/resources

cancercelllines; CVCL_Y545
Cell_Model_Passport; SIDM01855
DepMap; ACH-001634
DSMZCellDive; ACC-766

Encyclopedic resources

Wikidata; Q54947324

Gene expression databases

ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722

Entry history

Entry creation

07-Nov-2014

Last entry update

10-Apr-2025

Version number