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Cellosaurus U2OS-tetR (CVCL_XZ88)

[Text version]
Cell line name U2OS-tetR
Accession CVCL_XZ88
Resource Identification Initiative To cite this cell line use: U2OS-tetR (RRID:CVCL_XZ88)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Children:
CVCL_XZ89 (U2OS-tetR-PAmCherry1-KRAS G12D)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=31674905; DOI=10.7554/eLife.46393; PMCID=PMC7060040
Lee Y., Phelps C., Huang T., Mostofian B., Wu L., Zhang Y., Tao K., Chang Y.-H., Stork P.J.S., Gray J.W., Zuckerman D.M., Nan X.-L.
High-throughput, single-particle tracking reveals nested membrane domains that dictate KRas(G12D) diffusion and trafficking.
eLife 8:e46393.1-e46393.23(2019)

Cross-references
Encyclopedic resources Wikidata; Q98133789
Entry history
Entry creation19-Dec-2019
Last entry update10-Sep-2024
Version number9