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Cellosaurus JCaM1/LckR154K (CVCL_XF43)
Cell line name | JCaM1/LckR154K |
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Synonyms | JRK 154.6 |
Accession | CVCL_XF43 |
Resource Identification Initiative | To cite this cell line use: JCaM1/LckR154K (RRID:CVCL_XF43) |
Comments | Population: Caucasian. Characteristics: Parent cell line is deficient for LCK activity due to a deletion of exon 7. This cell line with a transfected LCK with the p.Arg154Lys substitution within the SH2 domain does not have a restored signaling activity (PubMed=8626636). Genetic integration: Method=Transfection/transduction; Gene=HGNC; 6524; LCK (Note=With p.Arg154Lys). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; SV40 large T antigen. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
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Disease | Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
Hierarchy | Parent: CVCL_XF41 (JCaM1/TAg) |
Sex of cell | Male |
Age at sampling | 14Y |
Category | Cancer cell line |
Publications | PubMed=8626636; DOI=10.1074/jbc.271.17.9976 PubMed=11231305; DOI=10.1046/j.1432-1327.2001.02028.x |
Cross-references | |
Cell line databases/resources | cancercelllines; CVCL_XF43 |
Encyclopedic resources | Wikidata; Q94326963 |
Entry history | |
Entry creation | 06-Sep-2019 |
Last entry update | 10-Sep-2024 |
Version number | 11 |