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Cellosaurus PC9-TGL (CVCL_XA18)

[Text version]
Cell line name PC9-TGL
Accession CVCL_XA18
Resource Identification Initiative To cite this cell line use: PC9-TGL (RRID:CVCL_XA18)
Comments Population: Chinese; Han and Japanese.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: In PubMed=19576624, PubMed=28283064 and the associated GEO data sets H2030-TGL is termed PC9 Parental.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Children:
CVCL_XA19 (PC9-BrM3)CVCL_XA20 (PC9-LeptoM)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=19576624; DOI=10.1016/j.cell.2009.04.030; PMCID=PMC2742946
Nguyen D.X., Chiang A.C., Zhang X.H.-F., Kim J.Y., Kris M.G., Ladanyi M., Gerald W.L., Massague J.
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Cell 138:51-62(2009)

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025; PMCID=PMC5405733
Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E., Massague J.
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_XA18
Encyclopedic resources Wikidata; Q98128513
Gene expression databases GEO; GSM354009
GEO; GSM354010
GEO; GSM2194116
GEO; GSM2194117
GEO; GSM2194118
Entry history
Entry creation06-Sep-2019
Last entry update10-Sep-2024
Version number9