| Cell line name |
1G5 [Human Jurkat derivative] |
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| Accession |
CVCL_X694 |
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| Resource Identification Initiative |
To cite this cell line use: 1G5 [Human Jurkat derivative] (RRID:CVCL_X694) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0367 (Jurkat E6.1) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8018390; DOI=10.1089/aid.1994.10.295
Aguilar-Cordova E., Chinen J., Donehower L., Lewis D.E., Belmont J.W.
A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects.
AIDS Res. Hum. Retroviruses 10:295-301(1994) |
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| Cross-references |
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| Cell line collections (Providers) |
BEI_Resources; ARP-1819
|
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| Cell line databases/resources |
cancercelllines; CVCL_X694
|
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| Encyclopedic resources |
Wikidata; Q54582896
|
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| Entry history |
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| Entry creation | 05-Sep-2014 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 19 |
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