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Cellosaurus U-2946 (CVCL_X503)

[Text version]
Cell line name U-2946
Accession CVCL_X503
Resource Identification Initiative To cite this cell line use: U-2946 (RRID:CVCL_X503)
Comments Part of: LL-100 blood cancer cell line panel.
Doubling time: 48 hours (PubMed=27907212); ~20-30 hours (DSMZ=ACC-795).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
HLA typing Source: DSMZCellDive=ACC-795
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*35:01:01,52:01:01
HLA-CC*04:01:01,12:02:02
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:02:01,02:01:02
HLA-DQDQA1*01:03:01,01:01:01
DQB1*05:01:01,06:01:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*01:01:01,15:02:01
Disease Diffuse large B-cell lymphoma activated B-cell type (NCIt: C36081)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-795

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133820,24
D3S135815,16
D5S81811,12
D7S8208,10
D8S117910,14
D13S31711,12
D16S53911,12
D18S5111,17
D19S43312
D21S1130
FGA20,23
Penta D9
Penta E11
TH016,9.3
TPOX9,12
vWA17,18

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Publications

PubMed=17926183; DOI=10.1080/10428190701636443
Fridberg M., Servin A., Anagnostaki L., Linderoth J., Berglund M., Soderberg O., Enblad G., Rosen A., Mustelin T., Jerkeman M., Persson J.L., Wingren A.G.
Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.
Leuk. Lymphoma 48:2221-2232(2007)

PubMed=27907212; DOI=10.1371/journal.pone.0167599; PMCID=PMC5132233
Quentmeier H., Drexler H.G., Hauer V., MacLeod R.A.F., Pommerenke C., Uphoff C.C., Zaborski M., Berglund M., Enblad G., Amini R.-M.
Diffuse large B cell lymphoma cell line U-2946: model for MCL1 inhibitor testing.
PLoS ONE 11:E0167599-E0167599(2016)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-795
Cell line databases/resources DSMZCellDive; ACC-795
Encyclopedic resources Wikidata; Q54973562
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Entry history
Entry creation05-Sep-2014
Last entry update19-Dec-2024
Version number18