ID   U-2946
AC   CVCL_X503
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   DSMZ; ACC-795
DR   DSMZCellDive; ACC-795
DR   Wikidata; Q54973562
RX   PubMed=17926183;
RX   PubMed=27907212;
RX   PubMed=31160637;
CC   Part of: LL-100 blood cancer cell line panel.
CC   Doubling time: 48 hours (PubMed=27907212); ~20-30 hours (DSMZ=ACC-795).
CC   HLA typing: A*01:01:01,02:01:01; B*35:01:01,52:01:01; C*04:01:01,12:02:02; DPA1*01:03:01,01:03:01; DPB1*04:02:01,02:01:02; DQA1*01:03:01,01:01:01; DQB1*05:01:01,06:01:01; DRA*01:01:01,01:02:02; DRB1*01:01:01,15:02:01 (DSMZCellDive=ACC-795).
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (PubMed=31160637).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ=ACC-795
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D18S51: 11,17
ST   D19S433: 12
ST   D21S11: 30
ST   D2S1338: 20,24
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 10,14
ST   FGA: 20,23
ST   Penta D: 9
ST   Penta E: 11
ST   TH01: 6,9.3
ST   TPOX: 9,12
ST   vWA: 17,18
DI   NCIt; C36081; Diffuse large B-cell lymphoma activated B-cell type
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 02-05-24; Version: 17
//
RX   PubMed=17926183; DOI=10.1080/10428190701636443;
RA   Fridberg M., Servin A., Anagnostaki L., Linderoth J., Berglund M.,
RA   Soderberg O., Enblad G., Rosen A., Mustelin T., Jerkeman M.,
RA   Persson J.L., Wingren A.G.;
RT   "Protein expression and cellular localization in two prognostic
RT   subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70
RT   and PKC-beta II in the non-germinal center group and poor survival in
RT   patients deficient in nuclear PTEN.";
RL   Leuk. Lymphoma 48:2221-2232(2007).
//
RX   PubMed=27907212; DOI=10.1371/journal.pone.0167599;
RA   Quentmeier H., Drexler H.G., Hauer V., MacLeod R.A.F., Pommerenke C.,
RA   Uphoff C.C., Zaborski M., Berglund M., Enblad G., Amini R.-M.;
RT   "Diffuse large B cell lymphoma cell line U-2946: model for MCL1
RT   inhibitor testing.";
RL   PLoS ONE 11:E0167599-E0167599(2016).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x;
RA   Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M.,
RA   MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.;
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218-8218(2019).
//