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Cellosaurus SK-OV-4 (CVCL_X008)

[Text version]
Cell line name SK-OV-4
Synonyms SKOV-4; SKOV4
Accession CVCL_X008
Resource Identification Initiative To cite this cell line use: SK-OV-4 (RRID:CVCL_X008)
Comments Problematic cell line: Contaminated. Shown to be a C-33 A derivative (PubMed=22710073).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00469.
Population: Caucasian.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (from parent cell line).
Disease Human papillomavirus-independent cervical squamous cell carcinoma (NCIt: C180841)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1094 (C-33 A)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cell line databases/resources cancercelllines; CVCL_X008
Biological sample resources BioSample; SAMN03151613
Encyclopedic resources Wikidata; Q54954503
Gene expression databases GEO; GSM851941
Entry history
Entry creation17-Jul-2014
Last entry update05-Oct-2023
Version number21