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Cellosaurus CPEK (CVCL_WY80)

[Text version]
Cell line name CPEK
Synonyms Canine Progenitor Epidermal Keratinocyte
Accession CVCL_WY80
Resource Identification Initiative To cite this cell line use: CPEK (RRID:CVCL_WY80)
Comments Characteristics: Useful for investigating the immunopathogenesis of inflammatory skin diseases.
Doubling time: 14.8 +- 1.50 hours (PubMed=18772565).
Omics: Transcriptomics; Microarray.
Miscellaneous: Sex of donor from personal communication of Girling, Peter.
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Beagle; VBO=VBO_0200131.
Sex of cell Male
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages Provider; CELLnTEC; -; https://cellntec.com/products/cpek
Publications

PubMed=18772565; DOI=10.1292/jvms.70.853
Shibata S., Maeda S., Tsuchida H., Fukata T.
Phenotypic analysis for a cell line of canine epidermal keratinocytes.
J. Vet. Med. Sci. 70:853-855(2008)

PubMed=20837364; DOI=10.1016/j.vetimm.2010.08.008
Shibata S., Maeda S., Kondo N., Chimura N., Inoue A., Fukata T.
Identification of the signaling pathway of TNF-alpha-induced CCL17/TARC transcription in a canine keratinocyte cell line.
Vet. Immunol. Immunopathol. 139:90-98(2011)

PubMed=20860556; DOI=10.1111/j.1365-3164.2010.00897.x
Shibata S., Maeda S., Kondo N., Inoue A., Maeda S., Chimura N., Fukata T.
Effect of recombinant canine interferon-gamma on granulocyte-macrophage colony-stimulating factor, transforming growth factor-beta and CC chemokine ligand 17 mRNA transcription in a canine keratinocyte cell line (CPEK).
Vet. Dermatol. 22:24-30(2011)

PubMed=23067725; DOI=10.1016/j.vetmic.2012.09.017
Mullin J., Carter S., Williams N., McEwan N., Nuttall T.
Transcription of canine Toll-like receptor 2, beta-defensin 1 and beta-defensin 103 in infected atopic skin, non-infected atopic skin, healthy skin and the CPEK cell line.
Vet. Microbiol. 162:700-706(2013)

PubMed=25190452; DOI=10.1186/s12917-014-0184-9; PMCID=PMC4172958
Pang L.Y., Argyle S.A., Kamida A., Morrison K.O., Argyle D.J.
The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro.
BMC Vet. Res. 10:184.1-184.11(2014)

PubMed=30268330; DOI=10.1016/j.tvjl.2018.09.001
Miyamoto R., Kurita S., Tani H., Ikeda T., Ishizaka M., Saima H., Kobayashi M., Tamura K., Bonkobara M.
Canine squamous cell carcinoma cell lines with high expression of survivin are sensitive to survivin inhibitor YM155.
Vet. J. 240:31-36(2018)

Cross-references
Encyclopedic resources Wikidata; Q93457518
Gene expression databases GEO; GSE77041
Entry history
Entry creation06-Sep-2019
Last entry update10-Apr-2025
Version number9