ID   CPEK
AC   CVCL_WY80
SY   Canine Progenitor Epidermal Keratinocyte
DR   GEO; GSE77041
DR   Wikidata; Q93457518
RX   PubMed=18772565;
RX   PubMed=20837364;
RX   PubMed=20860556;
RX   PubMed=23067725;
RX   PubMed=25190452;
RX   PubMed=30268330;
WW   Provider; CELLnTEC; -; https://cellntec.com/products/cpek
CC   Characteristics: Useful for investigating the immunopathogenesis of inflammatory skin diseases.
CC   Doubling time: 14.8 +- 1.50 hours (PubMed=18772565).
CC   Omics: Transcriptomics; Microarray.
CC   Miscellaneous: Sex of donor from personal communication of Girling, Peter.
CC   Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
CC   Breed/subspecies: Beagle; VBO=VBO_0200131.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 06-09-19; Last updated: 10-04-25; Version: 9
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RX   PubMed=18772565; DOI=10.1292/jvms.70.853;
RA   Shibata S., Maeda S., Tsuchida H., Fukata T.;
RT   "Phenotypic analysis for a cell line of canine epidermal
RT   keratinocytes.";
RL   J. Vet. Med. Sci. 70:853-855(2008).
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RX   PubMed=20837364; DOI=10.1016/j.vetimm.2010.08.008;
RA   Shibata S., Maeda S., Kondo N., Chimura N., Inoue A., Fukata T.;
RT   "Identification of the signaling pathway of TNF-alpha-induced
RT   CCL17/TARC transcription in a canine keratinocyte cell line.";
RL   Vet. Immunol. Immunopathol. 139:90-98(2011).
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RX   PubMed=20860556; DOI=10.1111/j.1365-3164.2010.00897.x;
RA   Shibata S., Maeda S., Kondo N., Inoue A., Maeda S., Chimura N.,
RA   Fukata T.;
RT   "Effect of recombinant canine interferon-gamma on
RT   granulocyte-macrophage colony-stimulating factor, transforming growth
RT   factor-beta and CC chemokine ligand 17 mRNA transcription in a canine
RT   keratinocyte cell line (CPEK).";
RL   Vet. Dermatol. 22:24-30(2011).
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RX   PubMed=23067725; DOI=10.1016/j.vetmic.2012.09.017;
RA   Mullin J., Carter S., Williams N., McEwan N., Nuttall T.;
RT   "Transcription of canine Toll-like receptor 2, beta-defensin 1 and
RT   beta-defensin 103 in infected atopic skin, non-infected atopic skin,
RT   healthy skin and the CPEK cell line.";
RL   Vet. Microbiol. 162:700-706(2013).
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RX   PubMed=25190452; DOI=10.1186/s12917-014-0184-9; PMCID=PMC4172958;
RA   Pang L.Y., Argyle S.A., Kamida A., Morrison K.O., Argyle D.J.;
RT   "The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has
RT   anti-proliferative and pro-apoptotic effects on canine cancer cell
RT   lines and cancer stem cells in vitro.";
RL   BMC Vet. Res. 10:184.1-184.11(2014).
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RX   PubMed=30268330; DOI=10.1016/j.tvjl.2018.09.001;
RA   Miyamoto R., Kurita S., Tani H., Ikeda T., Ishizaka M., Saima H.,
RA   Kobayashi M., Tamura K., Bonkobara M.;
RT   "Canine squamous cell carcinoma cell lines with high expression of
RT   survivin are sensitive to survivin inhibitor YM155.";
RL   Vet. J. 240:31-36(2018).
//