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Cellosaurus AT1BR (CVCL_WX69)

[Text version]
Cell line name AT1BR
Synonyms AT1Br; AT1 BR; Ataxia Telangiectasia 1 BRighton; BM0020
Accession CVCL_WX69
Resource Identification Initiative To cite this cell line use: AT1BR (RRID:CVCL_WX69)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Ataxia telangiectasia syndrome (NCIt: C2887)
Ataxia telangiectasia (ORDO: Orphanet_100)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C1HN (AT1BR44neo)
Originate from same individual CVCL_ZT25 ! AT1BR LCL
Sex of cell Male
Age at sampling 7Y
Category Finite cell line
Publications

PubMed=2903889; DOI=10.1080/09553008814552321
Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.
Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
Int. J. Radiat. Biol. 54:911-928(1988)

PubMed=7836839; DOI=10.1080/09553009414551951
Cole J., Arlett C.F.
Cloning efficiency and spontaneous mutant frequency in circulating T-lymphocytes in ataxia-telangiectasia patients.
Int. J. Radiat. Biol. 66:S123-S131(1994)

PubMed=10987302
Girard P.-M., Foray N., Stumm M., Waugh A.P.W., Riballo E., Maser R.S., Phillips W.P., Petrini J.H.J., Arlett C.F., Jeggo P.A.
Radiosensitivity in Nijmegen breakage syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects.
Cancer Res. 60:4881-4888(2000)

PubMed=11452007; DOI=10.1091/mbc.12.7.2109; PMCID=PMC55660
Montecucco A., Rossi R., Ferrari G., Scovassi A.I., Prosperi E., Biamonti G.
Etoposide induces the dispersal of DNA ligase I from replication factories.
Mol. Biol. Cell 12:2109-2118(2001)

PubMed=12082606; DOI=10.1038/sj.onc.1205596
Girard P.-M., Riballo E., Begg A.C., Waugh A.P.W., Jeggo P.A.
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Oncogene 21:4191-4199(2002)

PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029
Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J., Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P., Gennery A.R., Jeggo P.A., Lobrich M.
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Mol. Cell 16:715-724(2004)

PubMed=16714754; DOI=10.1259/bjr/83726649
Arlett C.F., Plowman P.N., Rogers P.B., Parris C.N., Abbaszadeh F., Green M.H.L., McMillan T.J., Bush C., Foray N., Lehmann A.R.
Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum.
Br. J. Radiol. 79:510-517(2006)

PubMed=16874298; DOI=10.1038/sj.emboj.7601255; PMCID=PMC1553186
Goodarzi A.A., Yu Y.-P., Riballo E., Douglas P., Walker S.A., Ye R.-Q., Harer C., Marchetti C., Morrice N., Jeggo P.A., Lees-Miller S.P.
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
EMBO J. 25:3880-3889(2006)

PubMed=18079351; DOI=10.1259/bjr/27072321
Arlett C.F., Green M.H.L., Rogers P.B., Lehmann A.R., Plowman P.N.
Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
Br. J. Radiol. 81:51-58(2008)

Cross-references
Encyclopedic resources Wikidata; Q93326280
Entry history
Entry creation06-Sep-2019
Last entry update29-Jun-2023
Version number6