ID   AT1BR
AC   CVCL_WX69
SY   AT1Br; AT1 BR; Ataxia Telangiectasia 1 BRighton; BM0020
DR   Wikidata; Q93326280
RX   PubMed=2903889;
RX   PubMed=7836839;
RX   PubMed=10987302;
RX   PubMed=11452007;
RX   PubMed=12082606;
RX   PubMed=15574327;
RX   PubMed=16714754;
RX   PubMed=16874298;
RX   PubMed=18079351;
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2887; Ataxia telangiectasia syndrome
DI   ORDO; Orphanet_100; Ataxia telangiectasia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_ZT25 ! AT1BR LCL
SX   Male
AG   7Y
CA   Finite cell line
DT   Created: 06-09-19; Last updated: 29-06-23; Version: 6
//
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett C.F., Green M.H.L., Priestley A., Harcourt S.A., Mayne L.V.;
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
//
RX   PubMed=7836839; DOI=10.1080/09553009414551951;
RA   Cole J., Arlett C.F.;
RT   "Cloning efficiency and spontaneous mutant frequency in circulating
RT   T-lymphocytes in ataxia-telangiectasia patients.";
RL   Int. J. Radiat. Biol. 66:S123-S131(1994).
//
RX   PubMed=10987302;
RA   Girard P.-M., Foray N., Stumm M., Waugh A.P.W., Riballo E., Maser R.S.,
RA   Phillips W.P., Petrini J.H.J., Arlett C.F., Jeggo P.A.;
RT   "Radiosensitivity in Nijmegen breakage syndrome cells is attributable
RT   to a repair defect and not cell cycle checkpoint defects.";
RL   Cancer Res. 60:4881-4888(2000).
//
RX   PubMed=11452007; DOI=10.1091/mbc.12.7.2109; PMCID=PMC55660;
RA   Montecucco A., Rossi R., Ferrari G., Scovassi A.I., Prosperi E.,
RA   Biamonti G.;
RT   "Etoposide induces the dispersal of DNA ligase I from replication
RT   factories.";
RL   Mol. Biol. Cell 12:2109-2118(2001).
//
RX   PubMed=12082606; DOI=10.1038/sj.onc.1205596;
RA   Girard P.-M., Riballo E., Begg A.C., Waugh A.P.W., Jeggo P.A.;
RT   "Nbs1 promotes ATM dependent phosphorylation events including those
RT   required for G1/S arrest.";
RL   Oncogene 21:4191-4199(2002).
//
RX   PubMed=15574327; DOI=10.1016/j.molcel.2004.10.029;
RA   Riballo E., Kuhne M., Rief N., Doherty A., Smith G.C.M., Recio M.-J.,
RA   Reis C., Dahm K., Fricke A., Krempler A., Parker A.R., Jackson S.P.,
RA   Gennery A.R., Jeggo P.A., Lobrich M.;
RT   "A pathway of double-strand break rejoining dependent upon ATM,
RT   Artemis, and proteins locating to gamma-H2AX foci.";
RL   Mol. Cell 16:715-724(2004).
//
RX   PubMed=16714754; DOI=10.1259/bjr/83726649;
RA   Arlett C.F., Plowman P.N., Rogers P.B., Parris C.N., Abbaszadeh F.,
RA   Green M.H.L., McMillan T.J., Bush C., Foray N., Lehmann A.R.;
RT   "Clinical and cellular ionizing radiation sensitivity in a patient
RT   with xeroderma pigmentosum.";
RL   Br. J. Radiol. 79:510-517(2006).
//
RX   PubMed=16874298; DOI=10.1038/sj.emboj.7601255; PMCID=PMC1553186;
RA   Goodarzi A.A., Yu Y.-P., Riballo E., Douglas P., Walker S.A., Ye R.-Q.,
RA   Harer C., Marchetti C., Morrice N., Jeggo P.A., Lees-Miller S.P.;
RT   "DNA-PK autophosphorylation facilitates Artemis endonuclease
RT   activity.";
RL   EMBO J. 25:3880-3889(2006).
//
RX   PubMed=18079351; DOI=10.1259/bjr/27072321;
RA   Arlett C.F., Green M.H.L., Rogers P.B., Lehmann A.R., Plowman P.N.;
RT   "Minimal ionizing radiation sensitivity in a large cohort of xeroderma
RT   pigmentosum fibroblasts.";
RL   Br. J. Radiol. 81:51-58(2008).
//