• Mutation; RGD; 3205; Nras; Simple; p.Gly13Val (c.38_39GC>TT); Zygosity=Unspecified (from inference of genetic background of other Eker-derived cell lines).
  
• Mutation; RGD; 3205; Nras; Simple; p.Val14Ile (c.40G>A); Zygosity=Unspecified (from inference of genetic background of other Eker-derived cell lines).
  
• Mutation; RGD; 3205; Nras; Simple; p.Ala18Val (c.53C>T); Zygosity=Unspecified (from inference of genetic background of other Eker-derived cell lines).
  
• Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (from inference of genetic background of other Eker-derived cell lines).
  

CLPUB00521
Freed J.J., Howard S., Lerro A.V., Dodson L.A., Sesok D., Knudson A.G. Jr.
Hereditary renal tumors in the rat: cell lines from adenocarcinomas induced by the Eker mutation.
Proc. Am. Assoc. Cancer Res. 31:317-317(1990)

PubMed=8419937; DOI=10.1073/pnas.90.1.327; PMCID=PMC45653
Hino O., Klein-Szanto A.J.P., Freed J.J., Testa J.R., Brown D.Q., Vilensky M., Yeung R.S.W., Tartof K.D., Knudson A.G. Jr.
Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.
Proc. Natl. Acad. Sci. U.S.A. 90:327-331(1993)

PubMed=7559744; DOI=10.1007/BF01197777
Hino O., Kobayashi E., Nishizawa M., Kubo Y., Kobayashi T., Hirayama Y., Takai S., Kikuchi Y., Tsuchiya H., Orimoto K., Kajino K., Takahara T.
Renal carcinogenesis in the Eker rat.
J. Cancer Res. Clin. Oncol. 121:602-605(1995)

PubMed=11011112; DOI=10.1111/j.1349-7006.2000.tb01027.x; PMCID=PMC5926447
Majima S., Kajino K., Fukuda T., Otsuka F., Hino O.
A novel gene 'Niban' upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.
Jpn. J. Cancer Res. 91:869-874(2000)