• Mutation; RGD; 3205; Nras; Simple; p.Gly13Val (c.38_39GC>TT); Zygosity=Unspecified (from inference of genetic background of other Eker-derived cell lines).
  
• Mutation; RGD; 3205; Nras; Simple; p.Val14Ile (c.40G>A); Zygosity=Unspecified (from inference of genetic background of other Eker-derived cell lines).
  
• Mutation; RGD; 3205; Nras; Simple; p.Ala18Val (c.53C>T); Zygosity=Unspecified (from inference of genetic background of other Eker-derived cell lines).
  
• Mutation; RGD; 3908; Tsc2; Simple; p.Val1272fs; Zygosity=Heterozygous; Note=Insertion of a 5 kb retrotransposon (from inference of genetic background of other Eker-derived cell lines).
  

CLPUB00521
Freed J.J., Howard S., Lerro A.V., Dodson L.A., Sesok D., Knudson A.G. Jr.
Hereditary renal tumors in the rat: cell lines from adenocarcinomas induced by the Eker mutation.
Proc. Am. Assoc. Cancer Res. 31:317-317(1990)

PubMed=1868463
Funaki K., Everitt J.I., Oshimura M., Freed J.J., Knudson A.G. Jr., Walker C.L.
Hereditary renal cell carcinoma in the rat associated with nonrandom loss of chromosomes 5 and 6.
Cancer Res. 51:4415-4422(1991)

PubMed=8419937; DOI=10.1073/pnas.90.1.327; PMCID=PMC45653
Hino O., Klein-Szanto A.J.P., Freed J.J., Testa J.R., Brown D.Q., Vilensky M., Yeung R.S.W., Tartof K.D., Knudson A.G. Jr.
Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.
Proc. Natl. Acad. Sci. U.S.A. 90:327-331(1993)