| Cell line name |
SupT1-R5 |
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| Synonyms |
SupT1-CCR5 |
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| Accession |
CVCL_WU89 |
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| Resource Identification Initiative |
To cite this cell line use: SupT1-R5 (RRID:CVCL_WU89) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Caution: There seem to be at least 6 different cell lines derived from Sup-T1 by transfection of human CCR5: Sup-T1-CCR5 (Cellosaurus=CVCL_X633), SupT1.CCR5 (Cellosaurus=CVCL_WU88), SupT1-R5 (Cellosaurus=CVCL_WU89), Sup-T1 CCR5+ H6 (Cellosaurus=CVCL_A9NU), Sup-T1 CCR5+ L23 (Cellosaurus=CVCL_A9NV) and Sup-T1 CCR5+ M10 (Cellosaurus=CVCL_A9NW).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1714 (SUP-T1) |
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| Sex of cell |
Male |
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| Age at sampling |
8Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=24162716; DOI=10.1182/blood-2013-08-521229; PMCID=PMC3879906
Didigu C.A., Wilen C.B., Wang J.-B., Duong J., Secreto A.J., Danet-Desnoyers G.-a., Riley J.L., Gregory P.D., June C.H., Holmes M.C., Doms R.W.
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
Blood 123:61-69(2014) PubMed=25253335; DOI=10.1128/JVI.01543-14; PMCID=PMC4249123
Herold N., Anders-Osswein M., Glass B., Eckhardt M., Muller B., Krausslich H.-G.
HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis.
J. Virol. 88:13956-13970(2014) PubMed=28233807; DOI=10.1038/srep43231; PMCID=PMC5324126
Fun A., Mok H.P., Wills M.R., Lever A.M.
A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoir.
Sci. Rep. 7:43231-43231(2017) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WU89
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| Encyclopedic resources |
Wikidata; Q98132878
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| Entry history |
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| Entry creation | 05-Jul-2019 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 13 |
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