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Cellosaurus VR-ALL (CVCL_WR52)

[Text version]
Cell line name VR-ALL
Accession CVCL_WR52
Resource Identification Initiative To cite this cell line use: VR-ALL (RRID:CVCL_WR52)
Comments Doubling time: ~56 hours (PubMed=29719609).
Omics: Deep exome analysis.
Miscellaneous: STR profile and sequence variation from personal communication of Takam Kamga, Paul.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:3386; EPHA2; Simple; p.Arg876His (c.2627G>A); ClinVar=VCV000259391; Zygosity=Heterozygous (Direct_author_submission).
  • Mutation; HGNC; HGNC:6188; JAG1; Simple; p.Pro871Arg (c.2612C>G); ClinVar=VCV000042475; Zygosity=Unspecified (PubMed=29719609).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Lys1821Asn; Zygosity=Heterozygous (Direct_author_submission).
  • Mutation; HGNC; HGNC:7883; NOTCH3; Simple; p.Val1952Met (c.5854G>A); ClinVar=VCV000256146; Zygosity=Heterozygous (Direct_author_submission).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 20Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D1S165617.3
D2S44111,12
D2S133817,19
D3S135814,18
D5S81811,12
D7S82011
D8S117913
D10S124814,16
D12S39118,19
D13S31712,13
D16S53911,13
D18S5112,17
D19S43314
D21S1128,30
D22S104515,16
DYS39111
FGA21,24
Penta D12,13
Penta E10
TH016,9
TPOX8,11
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=29719609; DOI=10.18632/oncotarget.24836; PMCID=PMC5915076
Takam Kamga P., Dal Collo G., Bassi G., Midolo M., Delledonne M., Chilosi M., Bonifacio M., Krampera M.
Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway.
Oncotarget 9:18341-18350(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WR52
Encyclopedic resources Wikidata; Q98134569
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number10