ID   VR-ALL
AC   CVCL_WR52
DR   cancercelllines; CVCL_WR52
DR   Wikidata; Q98134569
RX   PubMed=29719609;
CC   Doubling time: ~56 hours (PubMed=29719609).
CC   Sequence variation: Mutation; HGNC; HGNC:3386; EPHA2; Simple; p.Arg876His (c.2627G>A); ClinVar=VCV000259391; Zygosity=Heterozygous (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:6188; JAG1; Simple; p.Pro871Arg (c.2612C>G); ClinVar=VCV000042475; Zygosity=Unspecified (PubMed=29719609).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Lys1821Asn; Zygosity=Heterozygous (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:7883; NOTCH3; Simple; p.Val1952Met (c.5854G>A); ClinVar=VCV000256146; Zygosity=Heterozygous (Direct_author_submission).
CC   Omics: Deep exome analysis.
CC   Miscellaneous: STR profile and sequence variation from personal communication of Takam Kamga, Paul.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 14,16
ST   D12S391: 18,19
ST   D13S317: 12,13
ST   D16S539: 11,13
ST   D18S51: 12,17
ST   D19S433: 14
ST   D1S1656: 17.3
ST   D21S11: 28,30
ST   D22S1045: 15,16
ST   D2S1338: 17,19
ST   D2S441: 11,12
ST   D3S1358: 14,18
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 13
ST   DYS391: 11
ST   FGA: 21,24
ST   Penta D: 12,13
ST   Penta E: 10
ST   TH01: 6,9
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   20Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 19-12-24; Version: 10
//
RX   PubMed=29719609; DOI=10.18632/oncotarget.24836; PMCID=PMC5915076;
RA   Takam Kamga P., Dal Collo G., Bassi G., Midolo M., Delledonne M.,
RA   Chilosi M., Bonifacio M., Krampera M.;
RT   "Characterization of a new B-ALL cell line with constitutional defect
RT   of the Notch signaling pathway.";
RL   Oncotarget 9:18341-18350(2018).
//