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Cellosaurus Jurkat E6.1 NF-kappaB::eGFP (CVCL_WN96)

[Text version]
Cell line name Jurkat E6.1 NF-kappaB::eGFP
Accession CVCL_WN96
Resource Identification Initiative To cite this cell line use: Jurkat E6.1 NF-kappaB::eGFP (RRID:CVCL_WN96)
Comments Population: Caucasian.
Characteristics: The eGFP reporter gene is under control of a NF-kappaB promoter element.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_WN97 (JE6-1REP-iNKT)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=25500904; DOI=10.1038/srep07438; PMCID=PMC4262884
Ratzinger F., Haslacher H., Poeppl W., Hoermann G., Kovarik J.J., Jutz S., Steinberger P., Burgmann H., Pickl W.F., Schmetterer K.G.
Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity.
Sci. Rep. 4:7438-7438(2014)

PubMed=29029399; DOI=10.18632/oncotarget.17615; PMCID=PMC5630299
Jutz S., Hennig A., Paster W., Asrak O., Dijanovic D., Kellner F., Pickl W.F., Huppa J.B., Leitner J., Steinberger P.
A cellular platform for the evaluation of immune checkpoint molecules.
Oncotarget 8:64892-64906(2017)

PubMed=31092850; DOI=10.1038/s41598-019-43529-4; PMCID=PMC6520406
Humeniuk P., Geiselhart S., Battin C., Webb T.J., Steinberger P., Paster W., Hoffmann-Sommergruber K.
Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor.
Sci. Rep. 9:7426-7426(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WN96
Encyclopedic resources Wikidata; Q94332818
Entry history
Entry creation05-Jul-2019
Last entry update19-Dec-2024
Version number12