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Cellosaurus RBM1-IT4 (CVCL_WK99)

[Text version]
Cell line name RBM1-IT4
Synonyms Renal cancer Bone Metastasis 1-Intra Tibial 4
Accession CVCL_WK99
Resource Identification Initiative To cite this cell line use: RBM1-IT4 (RRID:CVCL_WK99)
Comments Characteristics: Established from a xenograft obtained by intratibial injection of the parent cell line in nude mice.
Derived from site: Metastatic; Bone, left humerus; UBERON=UBERON_0000976.
Sequence variations
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Asp179Thrfs*21 (c.535delG); Zygosity=Hemizygous (PubMed=17332933).
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5T98 (RBM1 [Human renal cell carcinoma])
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=12131367; DOI=10.1016/S0022-5347(05)64743-X
Weber K.L., Pathak S., Multani A.S., Price J.E.
Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model.
J. Urol. 168:774-779(2002)

PubMed=12782601
Weber K.L., Doucet M., Price J.E., Baker C., Kim S.J., Fidler I.J.
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
Cancer Res. 63:2940-2947(2003)

PubMed=17332933; DOI=10.3892/ijo.30.4.937
Karashima T., Inoue K., Fukata S., Iiyama T., Kurabayashi A., Kawada C., Shuin T.
Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice.
Int. J. Oncol. 30:937-945(2007)

Cross-references
Encyclopedic resources Wikidata; Q98128844
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number8