ID   RBM1-IT4
AC   CVCL_WK99
SY   Renal cancer Bone Metastasis 1-Intra Tibial 4
DR   Wikidata; Q98128844
RX   PubMed=12131367;
RX   PubMed=12782601;
RX   PubMed=17332933;
CC   Characteristics: Established from a xenograft obtained by intratibial injection of the parent cell line in nude mice.
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; p.Asp179Thrfs*21 (c.535delG); Zygosity=Hemizygous (PubMed=17332933).
CC   Derived from site: Metastatic; Bone, left humerus; UBERON=UBERON_0000976.
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5T98 ! RBM1 [Human renal cell carcinoma]
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 19-12-24; Version: 8
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RX   PubMed=12131367; DOI=10.1016/S0022-5347(05)64743-X;
RA   Weber K.L., Pathak S., Multani A.S., Price J.E.;
RT   "Characterization of a renal cell carcinoma cell line derived from a
RT   human bone metastasis and establishment of an experimental nude mouse
RT   model.";
RL   J. Urol. 168:774-779(2002).
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RX   PubMed=12782601;
RA   Weber K.L., Doucet M., Price J.E., Baker C., Kim S.J., Fidler I.J.;
RT   "Blockade of epidermal growth factor receptor signaling leads to
RT   inhibition of renal cell carcinoma growth in the bone of nude mice.";
RL   Cancer Res. 63:2940-2947(2003).
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RX   PubMed=17332933; DOI=10.3892/ijo.30.4.937;
RA   Karashima T., Inoue K., Fukata S., Iiyama T., Kurabayashi A.,
RA   Kawada C., Shuin T.;
RT   "Blockade of the vascular endothelial growth factor-receptor 2 pathway
RT   inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the
RT   kidney but not in the bone of nude mice.";
RL   Int. J. Oncol. 30:937-945(2007).
//