| Cell line name |
SW1573/2R250 |
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| Synonyms |
SW-1573/2R250; 2R250 |
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| Accession |
CVCL_WG77 |
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| Resource Identification Initiative |
To cite this cell line use: SW1573/2R250 (RRID:CVCL_WG77) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
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| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
|
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| Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_WG71 (SW1573/2R160) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | CLPUB00485
Kuiper C.M., Broxterman H.J., Baas F., Schuurhuis G.J., Haisma H.J., Scheffer G.L., Lankelma J., Pinedo H.M.
Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin.
J. Cell. Pharmacol. 1:35-41(1990) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WG77
|
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| Encyclopedic resources |
Wikidata; Q98132921
|
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| Entry history |
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| Entry creation | 24-May-2019 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 8 |
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