ID   SW1573/2R250
AC   CVCL_WG77
SY   SW-1573/2R250; 2R250
DR   cancercelllines; CVCL_WG77
DR   Wikidata; Q98132921
RX   CelloPub=CLPUB00485;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C2923; Minimally invasive lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_WG71 ! SW1573/2R160
SX   Female
AG   44Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 8
//
RX   CelloPub=CLPUB00485;
RA   Kuiper C.M., Broxterman H.J., Baas F., Schuurhuis G.J., Haisma H.J.,
RA   Scheffer G.L., Lankelma J., Pinedo H.M.;
RT   "Drug transport variants without P-glycoprotein overexpression from a
RT   human squamous lung cancer cell line after selection with doxorubicin.";
RL   J. Cell. Pharmacol. 1:35-41(1990).
//