Cellosaurus cell line PC-53A (CVCL

Cellosaurus PC-53A (CVCL_W803)

Cross-references
Cell line name	PC-53A
Synonyms	PC53A
Accession	CVCL_W803
Resource Identification Initiative	To cite this cell line use: PC-53A (RRID:CVCL_W803)
Comments	Characteristics: Established at the final progression phase. Doubling time: 70-80 hours (PubMed=2314113). Omics: Array-based CGH. Omics: Deep exome analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123). Mutation; HGNC; HGNC:8619; PAX5; Simple; p.Arg38His (c.113G>A); Zygosity=Heterozygous (PubMed=34940123).
Disease	Adult B acute lymphoblastic leukemia (NCIt: C9143) Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_W802 ! PC-53
Sex of cell	Female
Age at sampling	34Y
Category	Cancer cell line
Publications	PubMed=2314113; DOI=10.1016/0145-2126(90)90047-D Tarella C., Pregno P., Gallo E., Caracciolo D., Stefani S., Barletta C., Lanfrancone L., Ferrero D. Establishment from an adult leukemic patient of two novel precursor B cell lines with different growth modality. Leuk. Res. 14:177-184(1990) DOI=10.1016/B978-0-12-221970-2.50457-5 Drexler H.G. The leukemia-lymphoma cell line factsbook. (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001) PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001 Quentmeier H., Pommerenke C., Drexler H.G. Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression. Curr. Issues Mol. Biol. 43:2147-2156(2021)
Encyclopedic resources	Wikidata; Q54938460
Gene expression databases	ArrayExpress; E-MTAB-11038 ArrayExpress; E-MTAB-11039
Entry history
Entry creation	17-Jul-2014
Last entry update	19-Dec-2024
Version number	10