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Cellosaurus Melan-a Hm (CVCL_W079)

[Text version]
Cell line name Melan-a Hm
Synonyms melan-a Hm
Accession CVCL_W079
Resource Identification Initiative To cite this cell line use: Melan-a Hm (RRID:CVCL_W079)
Comments Characteristics: Transfected with a chimeric tyrosine-protein kinase receptor composed of extracellular part of human EGFR and the intracellular part of Xmrk. Stimulation of the chimera with EGF induces activation of the xmrk kinase domain.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR (Note=Extracellular domain).
Genetic integration: Method=Transfection; Gene=UniProtKB; P13388; Xiphophorus maculatus Xmrk (Note=Intracellular domain).
Derived from site: In situ; Trunk, skin; UBERON=UBERON_0001085.
Cell type: Melanocyte of skin; CL=CL_1000458.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_4624 (Melan-a)
Sex of cell Sex unspecified
Age at sampling 18FD
Category Spontaneously immortalized cell line
Publications

PubMed=11734563; DOI=10.1074/jbc.M110684200
Wellbrock C., Weisser C., Geissinger E., Troppmair J., Schartl M.
Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling.
J. Biol. Chem. 277:6443-6454(2002)

Cross-references
Anatomy/cell type resources BTO; BTO_0005424
Encyclopedic resources Wikidata; Q54905174
Entry history
Entry creation16-Apr-2014
Last entry update19-Dec-2024
Version number11