ID   Melan-a Hm
AC   CVCL_W079
SY   melan-a Hm
DR   BTO; BTO_0005424
DR   Wikidata; Q54905174
RX   PubMed=11734563;
CC   Characteristics: Transfected with a chimeric tyrosine-protein kinase receptor composed of extracellular part of human EGFR and the intracellular part of Xmrk. Stimulation of the chimera with EGF induces activation of the xmrk kinase domain.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR (Note=Extracellular domain).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P13388; Xiphophorus maculatus Xmrk (Note=Intracellular domain).
CC   Derived from site: In situ; Trunk, skin; UBERON=UBERON_0001085.
CC   Cell type: Melanocyte of skin; CL=CL_1000458.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4624 ! Melan-a
SX   Sex unspecified
AG   18FD
CA   Spontaneously immortalized cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 11
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RX   PubMed=11734563; DOI=10.1074/jbc.M110684200;
RA   Wellbrock, Claudia
RA   Weisser, Christin
RA   Geissinger, Eva
RA   Troppmair, Jakob
RA   Schartl, Manfred
RT   "Activation of p59(Fyn) leads to melanocyte dedifferentiation by
RT   influencing MKP-1-regulated mitogen-activated protein kinase
RT   signaling.";
RL   J. Biol. Chem. 277:6443-6454(2002).
//