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Cellosaurus SCCOHT-1 (CVCL_VU69)

[Text version]
Cell line name SCCOHT-1
Synonyms SCCOHT1; Small Cell Carcinoma of the Ovary, Hypercalcemic Type-1
Accession CVCL_VU69
Resource Identification Initiative To cite this cell line use: SCCOHT-1 (RRID:CVCL_VU69)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 38.1 hours (PubMed=22581215).
Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 11100; SMARCA4; Simple; p.Arg1077Ter (c.3229C>T); ClinVar=VCV001692588; Zygosity=Heterozygous (DepMap).
Disease Ovarian small cell carcinoma, hypercalcemic type (NCIt: C40439)
Small cell carcinoma of the ovary (ORDO: Orphanet_370396)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 31Y
Category Cancer cell line
Publications

PubMed=22581215; DOI=10.3892/ijo.2012.1468
Otte A., Gohring G., Steinemann D., Schlegelberger B., Groos S., Langer F., Kreipe H.-H., Schambach A., Neumann T., Hillemanns P., Park-Simon T.-W., Hass R.
A tumor-derived population (SCCOHT-1) as cellular model for a small cell ovarian carcinoma of the hypercalcemic type.
Int. J. Oncol. 41:765-775(2012)

PubMed=26356327; DOI=10.1002/path.4633
Karnezis A.N., Wang Y.-M., Ramos P., Hendricks W.P.D., Oliva E., D'Angelo E., Prat J., Nucci M.R., Nielsen T.O., Chow C., Leung S., Kommoss F., Kommoss S., Silva A., Ronnett B.M., Rabban J.T. III, Bowtell D.D.L., Weissman B.E., Trent J.M., Gilks C.B., Huntsman D.G.
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
J. Pathol. 238:389-400(2016)

Cross-references
Cell line collections (Providers) Millipore; SCC437
Cell line databases/resources cancercelllines; CVCL_VU69
Cell_Model_Passport; SIDM01866
DepMap; ACH-001279
Anatomy/cell type resources BTO; BTO:0005853
Encyclopedic resources Wikidata; Q98129384
Gene expression databases GEO; GSM1622408
GEO; GSM2748144
GEO; GSM2748145
GEO; GSM2748146
GEO; GSM2748147
GEO; GSM2748148
GEO; GSM2748149
Entry history
Entry creation24-May-2019
Last entry update30-Jan-2024
Version number11