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Cellosaurus QIMR-SB2b (CVCL_VS52)

[Text version]
Cell line name QIMR-SB2b
Synonyms SB2b; QIMR-B010
Accession CVCL_VS52
Resource Identification Initiative To cite this cell line use: QIMR-SB2b (RRID:CVCL_VS52)
Comments Doubling time: 108.7 +- 6.9 hours (PubMed=30894629).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, right parietal lobe; UBERON=UBERON_0002803.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (QCell).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Heterozygous (QCell).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Ala289Val (c.866C>T); ClinVar=VCV000376209; Zygosity=Heterozygous (QCell).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.His304Tyr (c.910C>T); Zygosity=Heterozygous (QCell).
  • Mutation; HGNC; HGNC:6973; MDM2; Simple; p.Trp329Cys (c.987G>T); Zygosity=Heterozygous (QCell).
  • Mutation; HGNC; HGNC:7029; MET; Simple; p.Cys800Phe (c.2399G>T) (p.Cys818Phe, c.2453G>T); ClinVar=VCV000648391; Zygosity=Heterozygous (QCell).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Tyr1021His (c.3061T>C); ClinVar=VCV001691391; Zygosity=Heterozygous (QCell).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): PubMed=30894629

Markers:
AmelogeninX,Y
CSF1PO10
D5S81811,13
D7S82011,12
D13S31712
D16S5399,12
D21S1128,32
TH016,7
TPOX9,10
vWA17

Run an STR similarity search on this cell line
Web pages Provider; Qcell; -; https://www.qimrberghofer.edu.au/commercial-collaborations/partner-with-us/q-cell/
Publications

PubMed=30894629; DOI=10.1038/s41598-019-41277-z; PMCID=PMC6427001
Stringer B.W., Day B.W., D'Souza R.C.J., Jamieson P.R., Ensbey K.S., Bruce Z.C., Lim Y.-C., Goasdoue K., Offenhauser C., Akgul S., Allan S., Robertson T., Lucas P.G., Tollesson G., Campbell S., Winter C., Do H.-D., Dobrovic A., Inglis P.-L., Jeffree R.L., Johns T.G., Boyd A.W.
A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Sci. Rep. 9:4902.1-4902.14(2019)

PubMed=31965010; DOI=10.1038/s41598-020-57850-w; PMCID=PMC6972897
Stringer B.W., Day B.W., D'Souza R.C.J., Jamieson P.R., Ensbey K.S., Bruce Z.C., Lim Y.-C., Goasdoue K., Offenhauser C., Akgul S., Allan S., Robertson T., Lucas P.G., Tollesson G., Campbell S., Winter C., Do H.-D., Dobrovic A., Inglis P.-L., Jeffree R.L., Johns T.G., Boyd A.W.
Publisher correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.
Sci. Rep. 10:1185.1-1185.14(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VS52
Encyclopedic resources Wikidata; Q98128769
Gene expression databases GEO; GSM3347678
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number12