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Cellosaurus Hmel-p16-1 (CVCL_VS14)

[Text version]
Cell line name Hmel-p16-1
Synonyms Human melanocytes lacking p16-1
Accession CVCL_VS14
Resource Identification Initiative To cite this cell line use: Hmel-p16-1 (RRID:CVCL_VS14)
Comments Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala76Cysfs*64 (c.225_243del19) (p.Arg90Valfs*76, c.268_286del19) (p16-Leiden); ClinVar=VCV000182411; Zygosity=Homozygous (PubMed=12759390).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VS06 (Hermes 1)
Sex of cell Male
Age at sampling 24Y
Category Finite cell line
Publications

PubMed=12759390; DOI=10.1093/jnci/95.10.723
Sviderskaya E.V., Gray-Schopfer V.C., Hill S.P., Smit N.P., Evans-Whipp T.J., Bond J., Hill L., Bataille V., Peters G., Kipling D., Wynford-Thomas D., Bennett D.C.
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
J. Natl. Cancer Inst. 95:723-732(2003)

Cross-references
Encyclopedic resources Wikidata; Q94213050
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number9