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Cellosaurus Hermes 1 (CVCL_VS06)

[Text version]
Cell line name Hermes 1
Synonyms Hermes1; Human extended-replication melanocytes-1
Accession CVCL_VS06
Resource Identification Initiative To cite this cell line use: Hermes 1 (RRID:CVCL_VS06)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala76Cysfs*64 (c.225_243del19) (p.Arg90Valfs*76, c.268_286del19) (p16-Leiden); ClinVar=VCV000182411; Zygosity=Homozygous (PubMed=12759390).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VS14 (Hmel-p16-1)
Sex of cell Male
Age at sampling 24Y
Category Telomerase immortalized cell line
Publications

PubMed=12759390; DOI=10.1093/jnci/95.10.723
Sviderskaya E.V., Gray-Schopfer V.C., Hill S.P., Smit N.P., Evans-Whipp T.J., Bond J., Hill L., Bataille V., Peters G., Kipling D., Wynford-Thomas D., Bennett D.C.
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
J. Natl. Cancer Inst. 95:723-732(2003)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783
Rose A.E., Poliseno L., Wang J.-H., Clark M., Pearlman A., Wang G.-M., Vega y Saenz de Miera E.C., Medicherla R., Christos P.J., Shapiro R., Pavlick A., Darvishian F., Zavadil J., Polsky D., Hernando E., Ostrer H., Osman I.
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

Cross-references
Encyclopedic resources Wikidata; Q94104090
Gene expression databases GEO; GSM555117
GEO; GSM555169
Entry history
Entry creation25-Feb-2019
Last entry update19-Dec-2024
Version number10