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Cellosaurus LL-iPSC-AECII (CVCL_VR37)

[Text version]
Cell line name LL-iPSC-AECII
Synonyms (LL)-iPSC-AECII; Long-Lasting-iPSC derived Alveolar Epithelial Cells type II
Accession CVCL_VR37
Resource Identification Initiative To cite this cell line use: LL-iPSC-AECII (RRID:CVCL_VR37)
Comments Population: Caucasian.
Characteristics: This cell line was established in a three step process: 1) iPSCs were generated from the parent fibroblast cell line; 2) these iPSCs were differentiated into alveolar type II epithelial cells (AEC type II); 3) these AEC type II cells were immortalized by transduction with human BMI1 and TERT (PubMed=30211653).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1066; BMI1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Alveolar type 2 fibroblast; CL=CL_4028006.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2769 (CCD-1112Sk)
Sex of cell Male
Age at sampling <1M
Category Telomerase immortalized cell line
Publications

PubMed=30211653; DOI=10.1152/ajplung.00357.2017
Tamo L., Hibaoui Y., Kallol S., Alves M.P., Albrecht C., Hostettler K.E., Feki A., Rougier J.-S., Abriel H., Knudsen L., Gazdhar A., Geiser T.
Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.
Am. J. Physiol. Lung Cell. Mol. Physiol. 315:L921-L932(2018)

Cross-references
Encyclopedic resources Wikidata; Q95982405
Entry history
Entry creation13-Nov-2018
Last entry update19-Dec-2024
Version number10