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Cellosaurus HCC1954-LCC2 (CVCL_VR26)

[Text version]
Cell line name HCC1954-LCC2
Synonyms HCC1954 LCC2; HCC1954-Latency Competent Cancer 2
Accession CVCL_VR26
Resource Identification Initiative To cite this cell line use: HCC1954-LCC2 (RRID:CVCL_VR26)
Comments Part of: Brain metastasis cell lines panel.
Population: East Indian.
Characteristics: After 3 months was recovered from the brain of healthy FOXN1nu mice that had been intracardially injected with the parent cell line.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR25 (HCC1954-LCC1)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO10
D2S133817,26
D3S135815,16
D5S81811
D7S82010,11
D8S117912,15
D13S3178,9
D16S5399,10,11
D18S5118
D19S43313,15.2
D21S1128,32.2
FGA22,23
TH016,7
TPOX8,9
vWA18,19

Run an STR similarity search on this cell line
Web pages https://apps.cnio.es/app/BrainMetastasis/CellLines
Publications

PubMed=27015306; DOI=10.1016/j.cell.2016.02.025
Malladi S., Macalinao D.G., Jin X., He L., Basnet H., Zou Y.-L., de Stanchina E., Massague J.
Metastatic latency and immune evasion through autocrine inhibition of WNT.
Cell 165:45-60(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VR26
Encyclopedic resources Wikidata; Q93982605
Gene expression databases GEO; GSM1875312
GEO; GSM1875313
GEO; GSM1875319
GEO; GSM1875320
GEO; GSM2066432
GEO; GSM2066436
GEO; GSM2066440
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number11