ID   HCC1954-LCC2
AC   CVCL_VR26
SY   HCC1954 LCC2; HCC1954-Latency Competent Cancer 2
DR   cancercelllines; CVCL_VR26
DR   GEO; GSM1875312
DR   GEO; GSM1875313
DR   GEO; GSM1875319
DR   GEO; GSM1875320
DR   GEO; GSM2066432
DR   GEO; GSM2066436
DR   GEO; GSM2066440
DR   Wikidata; Q93982605
RX   PubMed=27015306;
WW   https://apps.cnio.es/app/BrainMetastasis/CellLines
CC   Part of: Brain metastasis cell lines panel.
CC   Population: East Indian.
CC   Characteristics: After 3 months was recovered from the brain of healthy FOXN1nu mice that had been intracardially injected with the parent cell line.
CC   Sequence variation: Gene fusion; HGNC; 2092; CLTC + HGNC; 29559; VMP1; Name(s)=CLTC-VMP1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr163Cys (c.488A>G); ClinVar=VCV000127814; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8,9
ST   D16S539: 9,10,11
ST   D18S51: 18
ST   D19S433: 13,15.2
ST   D21S11: 28,32.2
ST   D2S1338: 17,26
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 12,15
ST   FGA: 22,23
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 18,19
DI   NCIt; C4017; Breast ductal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VR25 ! HCC1954-LCC1
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 05-10-23; Version: 11
//
RX   PubMed=27015306; DOI=10.1016/j.cell.2016.02.025;
RA   Malladi S., Macalinao D.G., Jin X., He L., Basnet H., Zou Y.-L.,
RA   de Stanchina E., Massague J.;
RT   "Metastatic latency and immune evasion through autocrine inhibition of
RT   WNT.";
RL   Cell 165:45-60(2016).
//