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Cellosaurus DKAT (CVCL_VQ65)

[Text version]
Cell line name DKAT
Accession CVCL_VQ65
Resource Identification Initiative To cite this cell line use: DKAT (RRID:CVCL_VQ65)
Comments Group: Patented cell line.
Group: Triple negative breast cancer (TNBC) cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-10322.
Characteristics: Highly tumorigenic. Only 10 DKAT cells are needed to form, in immunocompromised mice, xenograft tumors which display a range of epithelial and mesenchymal phenotypes (PubMed=23049838).
Doubling time: ~24 hours (PubMed=23049838).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VQ66 (DKAT-SCGM)
Sex of cell Female
Age at sampling 35Y
Category Cancer cell line
Publications

Patent=US20110085982
Seewaldt V.L., D'Amato N.C., Ostrander J.H.
DKAT cell line, a model for human triple-negative breast cancer.
Patent number US20110085982, 14-Apr-2011

PubMed=23049838; DOI=10.1371/journal.pone.0045684
D'Amato N.C., Ostrander J.H., Bowie M.L., Sistrunk C., Borowsky A.D., Cardiff R.D., Bell K., Young L.J.T., Simin K., Bachelder R.E., Delrow J.J., Dawson A., Yee L.D., Mrozek K., Clay T.M., Osada T., Seewaldt V.L.
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
PLoS ONE 7:E45684-E45684(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VQ65
Lonza; 1676
Encyclopedic resources Wikidata; Q93527903
Gene expression databases GEO; GSM820811
GEO; GSM820812
GEO; GSM820813
Entry history
Entry creation13-Nov-2018
Last entry update05-Oct-2023
Version number8